Anti-bacterial and Anti-quorum Sensing Properties of Selected Medicinal Plants from Nakhon Ratchasima Province, Thailand

Monton Visutthi


Quorum sensing (QS) is an intercellular signaling system and gene regulatory mechanism used by bacteria to respond to their cell population. Several physiological processes in pathogenesis of medically important bacteria are associated with this system. As QS controls bacterial virulence factors, the inhibition of the system is being considered as a novel approach for antibacterial substance. Hence, the present study was determined the effect of 48 Thai medicinal plant species on bacterial QS, Chromobacterium violaceum. Screening test using disc diffusion assay showed that five plant extracts exhibited anti-QS activity including Alpinia galanga Sw., Feronia limonia (L.) Swing, Millingtonia hortensis Linn., Oroxylum indicum (L.) Kurz., and Sesbania grandiflora (L.) Poiret. All extracts, except A. galanga, reduced strong violacein production. The sixteen extracts from 60 plant extracts which exhibited an antibacterial activity, were than determined minimal inhibitory concentration (MIC) and was observed the violacein production. The extract of A. galanga and P. betle gave MIC values at 5 and 1.25 mg/ml, respectively. In addition, the two extracts also possessed an anti-QS activity at sub-MIC. The results reveal the mode of action of botanical plants including anti-QS property and this activity should be further examinations.


Biology Pure and applied

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