Effect of Clove Extract on Sleeping Time in Mice

Kanyarat Sueksakit, Krittiya Thisayakorn, Wicheian Khueynok, Kanjana Sriyam, Darunee Pahusee, Nopparat Buddhakala


Insomnia leads to uncomfortable and affect for daily life. Sometime, it need to take a medicine for sedation. Clove (Syzygium aromaticum (L.) Merr.&L.M.Perry) is herb, mainly contains eugenol which benefits to treat a variety of diseases. The objective of this research was to study sedative effects of clove extract in mice. Our results showed that all the doses (250, 500, and 750 mg/kg) of clove extract in acacia solution showed significant difference (p<0.05) in the onset (the time from oral administration to the loss of righting reflex) as compared with the control group. However, 750 mg/kg clove extract showed significant difference (p<0.05) in duration time (the time from the loss of righting reflex to awakening) on sleeping time. In addition, 750 mg/kg clove extract showed the highest of the duration time 146.2±7.66 min as compared with the other doses. It is possible that clove extract may be able to help for relaxation. Also, we need to study the mechanism of action prior to the development of a natural product for sedation.



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Progress in Applied Science and Technology

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